Modified Bone Marrow Stromal Cells Therapy for Central Nervous System Disorders
نویسندگان
چکیده
This article concluded our serial studies on the therapeutic protective effects of modified bone marrow stromal cells on central nervous injury. Hope this will provide a prelusion of transition of central nervous disease treatment from experimental treatment to the idea of clinical application.
منابع مشابه
Induction of Bone Marrow Stromal Cells into Cholinergic-Like Cells by Nerve Growth Factor
Background: Bone marrow stromal cells (BMSC) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. However, the transdifferentiation of BMSC into cholinergic phenotype requires more investigation. Methods: BMSC were isolated from adult rats, pre-induced with β-mercaptoethanol (BME) and followed by nerve growth factor (NGF) indu...
متن کاملEffects of Co-Administration of Bone Marrow Stromal Cells and L-Carnitine on The Recovery of Damaged Ovaries by Performing Chemotherapy Model in Rat
Objective Chemotherapy may damage ovaries. L-carnitine (LC) as a type of flavonoid antioxidants and bone marrow stromal cells (BMSCs) as a type of mesenchymal stem cells may recover damaged ovaries. It seems that LC has favorable effects on differentiation, increasing lifespan and decreasing apoptosis in BMSCs. The aim of this study was to investigate the effects of co-administration of BMSCs a...
متن کاملBone Marrow Stromal Cells with the Granulocyte Colony-Stimulating Factor in the Management of Chemotherapy-Induced Ovarian Failure in a Rat Model
Background: Bone marrow stromal cells (BMSCs), as a type of mesenchymal stem cells, and the granulocyte colony-stimulating factor (G-CSF), as a type of growth factor, may recover damaged ovaries. The aim of the present study was to investigate the effects of the coadministration of BMSCs and the G-CSF on damaged ovaries after creating a chemotherapy model with cyclophosphamide (CTX) in rats.Met...
متن کاملA Study on Transdifferentiation of Bone Marrow Stromal Cells into Neuronal and Glial-Like Cells In Vitro by Different Inducers
Introduction: There are some evidences to suggest that bone marrow stromal cells (BMSCs) not only differentiate into mesodermal cells, but also adopt the fate of endodermal and ectodermal cell types. BMSCs can be a valuable cell source as an autograft for clinical application involving regeneration of the central nervous system. Bone marrow stromal cells can be expanded rapidly in vitro and can...
متن کاملMorphological changes in injured retinal pigment epithelium and photoreceptor cells after transplantation of stem cells into subretinal space
Introduction: Degenerative retinal diseases are main cause of irreversible blindness. Stem cells therapy is a promising way in these diseases. Therefore, mesenchymal stem cells because of its safety can produce degenerated cells and can play important role in treatment. The aim of this study was to examine morphological changes in injured retinal pigment epithelium (RPE) and photoreceptor cells...
متن کامل